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Keisuke Miyazawa Selected Research

Proteasome Endopeptidase Complex (Proteasome)

9/2021Induction of synergistic non-apoptotic cell death by simultaneously targeting proteasomes with bortezomib and histone deacetylase 6 with ricolinostat in head and neck tumor cells.
2/2015Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.
4/2012Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells.

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Keisuke Miyazawa Research Topics

Disease

24Neoplasms (Cancer)
09/2021 - 12/2002
9Leukemia
07/2020 - 09/2003
8Multiple Myeloma
01/2018 - 06/2006
7Lung Neoplasms (Lung Cancer)
05/2022 - 09/2003
7Myelodysplastic Syndromes (Myelodysplastic Syndrome)
09/2010 - 09/2003
6Breast Neoplasms (Breast Cancer)
01/2021 - 04/2012
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
08/2021 - 01/2011
5BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
03/2009 - 02/2002
4Thrombocytopenia (Thrombopenia)
09/2010 - 01/2003
4Anemia
09/2010 - 01/2005
3Carcinogenesis
08/2013 - 08/2006
3Colonic Neoplasms (Colon Cancer)
08/2013 - 06/2009
3Hepatocellular Carcinoma (Hepatoma)
02/2012 - 02/2006
3Refractory Anemia
09/2010 - 04/2003
3Cytopenia
09/2010 - 10/2004
3Infections
01/2010 - 04/2003
3Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
04/2003 - 12/2002
2Squamous Cell Carcinoma of Head and Neck
05/2022 - 01/2016
2Pancreatic Neoplasms (Pancreatic Cancer)
01/2022 - 01/2016
2Stomach Neoplasms (Stomach Cancer)
02/2011 - 02/2006
2Aplastic Anemia (Anemia, Hypoplastic)
07/2008 - 11/2004
2Primary Myelofibrosis (Myelosclerosis)
01/2007 - 04/2005
2Splenomegaly
01/2007 - 01/2005
2Mucormycosis
11/2003 - 09/2003
2Thrombosis (Thrombus)
11/2003 - 09/2003
2Autoimmune Diseases (Autoimmune Disease)
11/2003 - 04/2003
1Head and Neck Neoplasms (Head and Neck Cancer)
09/2021
1Endometrial Neoplasms (Endometrial Cancer)
04/2021
1Necrosis
12/2020
1Triple Negative Breast Neoplasms
01/2020
1Multiple Sclerosis
07/2019
1Starvation
04/2018
1Infertility (Sterility)
10/2016
1Type 2 Diabetes Mellitus (MODY)
07/2015
1Glioblastoma (Glioblastoma Multiforme)
11/2013

Drug/Important Bio-Agent (IBA)

11Vitamin K 2 (Vitamin K2)IBA
03/2020 - 09/2003
103-aminophenoxazoneIBA
11/2013 - 07/2005
7Bortezomib (Velcade)FDA Link
09/2021 - 03/2011
6MacrolidesIBA
08/2021 - 02/2015
6Clarithromycin (Biaxin)FDA LinkGeneric
12/2020 - 04/2012
5ErbB Receptors (EGF Receptor)IBA
01/2022 - 04/2018
5Proteasome InhibitorsIBA
09/2021 - 07/2013
5Anti-Bacterial Agents (Antibiotics)IBA
08/2021 - 02/2015
5Imatinib Mesylate (Gleevec)FDA Link
07/2020 - 01/2003
5menatetrenoneIBA
09/2010 - 09/2003
4Tyrosine Kinase InhibitorsIBA
08/2021 - 04/2018
4Azithromycin (Zithromax)FDA LinkGeneric
08/2021 - 11/2016
4Gefitinib (Iressa)FDA Link
07/2020 - 05/2015
3Cytostatic AgentsIBA
01/2022 - 01/2018
3Proteasome Endopeptidase Complex (Proteasome)IBA
09/2021 - 04/2012
3DNA (Deoxyribonucleic Acid)IBA
08/2021 - 07/2005
3Pharmaceutical PreparationsIBA
01/2020 - 03/2010
3Proteins (Proteins, Gene)FDA Link
07/2015 - 07/2008
3ATP dependent 26S protease (26S proteasome)IBA
05/2013 - 03/2011
3Prednisolone (Predate)FDA LinkGeneric
01/2007 - 11/2002
2Histone Deacetylase 6IBA
05/2022 - 09/2021
2ricolinostatIBA
05/2022 - 09/2021
2Drug CombinationsIBA
01/2022 - 01/2018
2Fingolimod Hydrochloride (FTY720)FDA Link
01/2022 - 07/2019
2Lapatinib (GW572016)FDA Link
01/2022 - 07/2019
2abemaciclibIBA
06/2020 - 01/2018
2Amino AcidsFDA Link
04/2018 - 01/2016
2Phosphotransferases (Kinase)IBA
05/2015 - 01/2005
2UbiquitinIBA
02/2015 - 04/2012
2Reactive Oxygen Species (Oxygen Radicals)IBA
11/2013 - 03/2010
2JNK Mitogen-Activated Protein KinasesIBA
11/2013 - 03/2009
2phenoxazineIBA
08/2013 - 01/2010
2Hemoglobins (Hemoglobin)IBA
09/2010 - 07/2005
2VitaminsIBA
12/2007 - 02/2006
2Interferon-alpha (Interferon Alfa)IBA
11/2003 - 02/2002
2Deferoxamine (Desferal)FDA LinkGeneric
11/2003 - 09/2003
2Inosine Triphosphate (ITP)IBA
04/2003 - 04/2003
2Immunoglobulin G (IgG)IBA
12/2002 - 11/2002
1SphingosineIBA
01/2022
1Phenylalanine (L-Phenylalanine)FDA Link
04/2021
1Alanine (L-Alanine)FDA Link
04/2021
1Estrogen Receptor alphaIBA
04/2021
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2021
1Indicators and Reagents (Reagents)IBA
01/2021
1Lansoprazole (Prevacid)FDA LinkGeneric
12/2020
1Proton Pump InhibitorsIBA
12/2020
1Progesterone Receptors (Progesterone Receptor)IBA
10/2020
1Therapeutic UsesIBA
07/2020
1ribociclibIBA
06/2020
1palbociclibIBA
06/2020
1Cisplatin (Platino)FDA LinkGeneric
01/2020
1Sorafenib (BAY 43-9006)FDA Link
07/2019
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
07/2019
1CyclinsIBA
01/2018
1Cyclin-Dependent Kinase 4IBA
01/2018
1VimentinIBA
11/2016
1Vinorelbine (Navelbine)FDA LinkGeneric
11/2016
1DNA-Binding Proteins (DNA Binding Protein)IBA
07/2015
1PotassiumIBA
07/2015
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
05/2015

Therapy/Procedure

27Therapeutics
08/2021 - 02/2002
8Drug Therapy (Chemotherapy)
08/2021 - 08/2006
5Aftercare (After-Treatment)
10/2011 - 11/2004
2Chemoprevention
03/2020 - 03/2011
2Splenectomy
01/2005 - 12/2002